On Liver Tryptophan Pyrrolase at Nitrobenzene Poisoning

Role of tryptophan pyrrolase in endotoxin poisoning.

Using substrate induction as a tool, we attempted to determine the role of tryptophan pyrrolase in the response to endotoxin in mice. Previous results have shown that the administration of the ld(50) of endotoxin lowers tryptophan pyrrolase activity. alpha-Methyltryptophan was found to maintain tryptophan pyrrolase activity above control levels in endotoxin-poisoned mice without increasing surv...

Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.

We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan was estimated by injecting rats with [ring-2-14-C]tryptophan and measuring respiratory 14-CO2. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown. Tryptophan loads also increase tryptophan b...

Tryptophan Catabolism by Tryptophan Pyrrolase in Rat Liver THE EFFECT OF TRYPTOPHAK LOADS AKD CHAKGES IN TRYPTOPHAN PYRROLASE ACTIVITY*

We investigated how changes in tryptophan pyrrolase activity and tryptophan loads affect the breakdown of tryptophan by tryptophan pyrrolase. Breakdown of tryptophan was estimated by injecting rats with [ring-ZJ%]tryptophan and measuring respiratory 14C02. We concluded, contrary to previous reports, that induction of tryptophan pyrrolase definitely will increase the rate of tryptophan breakdown...

Determination of tryptophan pyrrolase activity in rat liver homogenates.

A microsomal iron-porphyrin activator of rat liver tryptophan pyrrolase.

Tryptophan pyrrolase, the enzyme that catalyzes the oxidation of tryptophan to formylkynurenine, has been localized in the 11,000 X g supernatant fraction of mammalian liver homogenates (l), which contains microsomes and cell sap. In the course of the present investigations (Z), it was observed that the isolated microsomal fraction of rat liver is devoid of this enzyme. However, addition of thi...